Caspase 12 anticorps (N-Term)

N° du produit ABIN3042658

Détail du produit anti-Caspase 12 anticorps

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Épitope: AA 71-84, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Inactive caspase-12(CASP12) detection. Tested with WB, IHC-P in Human.

Séquence: KIFREHLWNS KKQL

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Inactive caspase-12(CASP12) detection. Tested with WB, IHC-P in Human.
Gene Name: caspase 12(gene/pseudogene)
Protein Name: Inactive caspase-12

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12(71-84aa KIFREHLWNSKKQL).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for CASP12 is approximately 0.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-Caspase 12 (ABIN3042658)

Zhao, Xiong, Mao, Meng, Lei, Li, Deng, Chen, Tu, Lu, Yang, He: "Atmospheric pressure room temperature plasma jets facilitate oxidative and nitrative stress and lead to endoplasmic reticulum stress dependent apoptosis in HepG2 cells." dans: PLoS ONE, Vol. 8, Issue 8, pp. e73665, (2013) (PubMed).

Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." dans: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

Détails sur Caspase 12

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Autre désignation: CASP12 (CASP12 Produits)

Synonymes: anticorps Caspase-12, anticorps CASP-12, anticorps CASP12P1, anticorps caspase 12, anticorps caspase 12 (gene/pseudogene), anticorps Casp12, anticorps CASP12

Sujet: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Synonyms: Apoptosis related cysteine protease antibody|CASP 12 antibody|CASP-12 antibody|casp12 antibody|CASP12P1 antibody|caspase 12(gene/pseudogene) antibody|caspase 12 pseudogene 1 antibody|Caspase 12 psuedogene 1 antibody|Caspase12 antibody|CASPC_HUMAN antibody|Inactive caspase-12 antibody|OTTHUMP00000207032 antibody|UNQ9415 antibody

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response