COL2A1 anticorps (C-Term)
-
- Antigène Voir toutes COL2A1 Anticorps
- COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
-
Épitope
- AA 1222-1241, C-Term
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp COL2A1 est non-conjugé
-
Application
- Western Blotting (WB)
- Fonction
- Rabbit IgG polyclonal antibody for Collagen alpha-1(II) chain(COL2A1) detection. Tested with WB in Human,Mouse,Rat.
- Séquence
- AFAGLGPREK GPDPLQYMRA
- Réactivité croisée (Details)
-
Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - Attributs du produit
-
Rabbit IgG polyclonal antibody for Collagen alpha-1(II) chain(COL2A1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: collagen, type II, alpha 1
Protein Name: Collagen alpha-1(II) chain - Purification
- Immunogen affinity purified.
- Immunogène
- A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen II(1222-1241aa AFAGLGPREKGPDPLQYMRA), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product COL2A1 Anticorps primaire
-
-
- Indications d'application
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Commentaires
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Agent conservateur
- Thimerosal (Merthiolate), Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Date de péremption
- 12 months
-
-
Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity." dans: Scientific reports, Vol. 6, pp. 27521, (2018) (PubMed).
: "A Human Chondrocyte-Derived In Vitro Model of Alcohol-Induced and Steroid-Induced Femoral Head Necrosis." dans: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 539-547, (2018) (PubMed).
: "Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro." dans: International journal of molecular medicine, Vol. 41, Issue 4, pp. 2150-2158, (2018) (PubMed).
: "Protective effects of baicalin on rabbit articular chondrocytes in vitro." dans: Experimental and therapeutic medicine, Vol. 13, Issue 4, pp. 1267-1274, (2017) (PubMed).
: "Effect of NGF From Venom of Chinese Cobra (Naja Atra)on Chondrocytes Proliferation and Metabolism In Vitro." dans: Journal of cellular biochemistry, (2017) (PubMed).
: "MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR." dans: American journal of translational research, Vol. 9, Issue 11, pp. 4963-4973, (2017) (PubMed).
: "Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3." dans: Scientific reports, Vol. 5, pp. 15101, (2016) (PubMed).
: "Protective effect of calcitonin on lumbar fusion-induced adjacent-segment disc degeneration in ovariectomized rat." dans: BMC musculoskeletal disorders, Vol. 16, pp. 342, (2016) (PubMed).
: "Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation." dans: Molecular medicine reports, Vol. 13, Issue 1, pp. 67-74, (2016) (PubMed).
: "Oral Resveratrol Prevents Osteoarthritis Progression in C57BL/6J Mice Fed a High-Fat Diet." dans: Nutrients, Vol. 8, Issue 4, pp. 233, (2016) (PubMed).
: "Use of a biological reactor and platelet-rich plasma for the construction of tissue-engineered bone to repair articular cartilage defects." dans: Experimental and therapeutic medicine, Vol. 12, Issue 2, pp. 711-719, (2016) (PubMed).
: "Chondroprotective effects of taurine in primary cultures of human articular chondrocytes." dans: The Tohoku journal of experimental medicine, Vol. 235, Issue 3, pp. 201-13, (2015) (PubMed).
: "Millimeter Wave Treatment Inhibits Apoptosis of Chondrocytes via Regulation Dynamic Equilibrium of Intracellular Free Ca (2+)." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 464161, (2015) (PubMed).
: "Promoting Effects on Proliferation and Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Four "Kidney-Tonifying" Traditional Chinese Herbs." dans: BioMed research international, Vol. 2015, pp. 792161, (2015) (PubMed).
: "Construction of tissue-engineered laryngeal cartilage with a hollow, semi-flared shape using poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as a scaffold." dans: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1482-1488, (2015) (PubMed).
: "Effects of TGF-β1 and alginate on the differentiation of rabbit bone marrow-derived mesenchymal stem cells into a chondrocyte cell lineage." dans: Experimental and therapeutic medicine, Vol. 10, Issue 3, pp. 995-1002, (2015) (PubMed).
: "Establishment of a rat model for osteoarthritis resulting from anterior cruciate ligament rupture and its significance." dans: Experimental and therapeutic medicine, Vol. 10, Issue 6, pp. 2035-2038, (2015) (PubMed).
: "Effect of JEZTC, a synthetic compound, on proliferation and phenotype maintenance of rabbit articular chondrocytes in vitro." dans: In vitro cellular & developmental biology. Animal, Vol. 50, Issue 10, pp. 982-91, (2014) (PubMed).
: "Microenvironment is involved in cellular response to hydrostatic pressures during chondrogenesis of mesenchymal stem cells." dans: Journal of cellular biochemistry, Vol. 115, Issue 6, pp. 1089-96, (2014) (PubMed).
: "Comparisons of rabbit bone marrow mesenchymal stem cell isolation and culture methods in vitro." dans: PLoS ONE, Vol. 9, Issue 2, pp. e88794, (2014) (PubMed).
: "
-
Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degeneration in ovariectomized rats and enhance Wnt/β-catenin pathway activity." dans: Scientific reports, Vol. 6, pp. 27521, (2018) (PubMed).
-
- Antigène
- COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
- Autre désignation
- COL2A1 (COL2A1 Produits)
- Synonymes
- anticorps ANFH, anticorps AOM, anticorps COL11A3, anticorps SEDC, anticorps Col2, anticorps Col2a, anticorps Col2a-1, anticorps Del1, anticorps Dmm, anticorps Lpk, anticorps M100856, anticorps Rgsc856, anticorps CG2A1A, anticorps COLLII, anticorps col2a1a, anticorps CB11, anticorps col2a1, anticorps coll2a1, anticorps fb38c06, anticorps fc10c01, anticorps wu:fb38c06, anticorps wu:fc10c01, anticorps collagen type II alpha 1 chain, anticorps collagen, type II, alpha 1, anticorps collagen, type II, alpha 1 L homeolog, anticorps collagen, type II, alpha 1 S homeolog, anticorps collagen, type II, alpha 1a, anticorps COL2A1, anticorps Col2a1, anticorps col2a1, anticorps col2a1.L, anticorps col2a1.S, anticorps col2a1a
- Sujet
-
Collagen, type II, alpha 1, also known as COL2A1, is a human gene which is the major collagen synthesized by chondrocvtes. COL2A1 is mapped to 12q13.11. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
Synonyms: Alpha 1 type II collagen antibody|Alpha-1 type II collagen antibody|AOM antibody|Cartilage collagen antibody|Chondrocalcin antibody|CO2A1_HUMAN antibody|COL11A3 antibody|COL2A1 antibody|COL2A1 protein antibody|Collagen alpha 1(II) chain precursor antibody|Collagen II alpha 1 polypeptide antibody|Collagen type II alpha 1(primary osteoarthritis spondyloepiphyseal dysplasia congenital) antibody|MGC131516 antibody|SEDC antibody - UniProt
- P02458
- Pathways
- Sensory Perception of Sound, Growth Factor Binding
-