MMP14 anticorps (Matrix Metallopeptidase 14 (Membrane-inserted)) (AA 557-582)

Details for Product anti-MMP14 Antibody No. ABIN3043408
Antigène
  • MMP1
  • MMP-14
  • MMP-X1
  • MT-MMP
  • MT-MMP 1
  • MT1-MMP
  • MT1MMP
  • MTMMP1
  • mmp-x1
  • mt1-mmp
  • mtmmp1
  • AI325305
  • MT-MMP-1
  • sabe
  • Mt1-mmp
  • cb386
  • sb:cb386
  • wu:fb72b09
  • mmp14
  • matrix metallopeptidase 14
  • matrix metallopeptidase 14 (membrane-inserted)
  • matrix metallopeptidase 14a (membrane-inserted)
  • matrix metallopeptidase 14 L homeolog
  • MMP14
  • mmp14
  • Mmp14
  • mmp14a
  • mmp14.L
Épitope
AA 557-582, C-Term
43
17
10
10
8
6
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
225
79
77
9
8
5
4
3
3
2
1
1
1
1
1
Hôte
Lapin
179
33
14
2
Clonalité
Polyclonal
Conjugué
Cet anticorp MMP14 est non-conjugé
12
10
10
7
7
7
2
2
2
2
2
2
2
2
1
Application
Western Blotting (WB)
189
114
86
27
23
18
14
14
7
5
3
1
Options
Fonction Rabbit IgG polyclonal antibody for Matrix metalloproteinase-14(MMP14) detection. Tested with WB in Human.
Immunogène A synthetic peptide corresponding to a sequence at the C-terminus of human MMP14 (557-582aa LAVFFFRRHGTPRRLLYCQRSLLDKV), different from the related mouse and rat sequences by one amino acid.
Séquence LAVFFFRRHG TPRRLLYCQR SLLDKV
Isotype IgG
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Matrix metalloproteinase-14(MMP14) detection. Tested with WB in Human.
Gene Name: matrix metallopeptidase 14 (membrane-inserted)
Protein Name: Matrix metalloproteinase-14
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others MMP14 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation MMP14 (MMP14 Antibody Extrait)
Sujet Matrix metalloproteinase-14, also called MT-MMP 1, is an enzyme that in humans is encoded by the MMP14 gene. The protein encoded by this gene is a member of the membrane-type MMP subfamily. This gene is mapped to 14q11.2. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene may be involved in actin cytoskeleton reorganization by cleaving PTK7. It acts as a positive regulator of cell growth and migration via activation of MMP15.

Synonyms: Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody
ID gène 4323
UniProt P50281
Pathways Autophagy
Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MMP14 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Images (Fournisseur)
Western Blotting (WB) image for anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 557-582), (C-Term) antibody (ABIN3043408) Anti- MMP14 Picoband antibody, Western blotting All lanes: Anti MMP14 at 0.5ug/ml La...
Produit citée dans: Tang, Pei, Yang, Wang, Wang, Gao, Li, Yang, Yang: "The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." dans: Scientific reports, Vol. 6, pp. 29975, 2018 (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." dans: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, 2018 (PubMed).

Li, Li, Zeng, Liu, Yang: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." dans: Renal failure, Vol. 39, Issue 1, pp. 265-272, 2017 (PubMed).

Shi, Wang, Zhang, Li, Guo, Li, Chen: "Effect of lentivirus-mediated uPA silencing on the proliferation and apoptosis of chondrocytes and the expression of MMPs." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 35, Issue 1, pp. 111-6, 2015 (PubMed).

Xiao, Li, Yu, Xiao, Hu, Tang, Zeng, He, Zeng, Ye, Xu: "MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer." dans: Oncology reports, Vol. 31, Issue 4, pp. 1832-8, 2014 (PubMed).

Zhou, Wu, Fu, Lv, Zhang: "Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer." dans: Oncology letters, Vol. 7, Issue 5, pp. 1395-1400, 2014 (PubMed).

Zhang, Sun, Zhang, Ge, Liu, Zhao, Lu, Fan: "Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5?2 signaling pathway." dans: BMC cancer, Vol. 14, pp. 193, 2014 (PubMed).

Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." dans: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, 2013 (PubMed).

Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." dans: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, 2012 (PubMed).

Dong, Yu, Yang, Jiang, Zhang: "Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis." dans: International journal of experimental pathology, Vol. 91, Issue 4, pp. 368-73, 2010 (PubMed).

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