PRKAR1A
Reactivité: Humain
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps ACRDYS1, anticorps ADOHR, anticorps CAR, anticorps CNC, anticorps CNC1, anticorps PKR1, anticorps PPNAD1, anticorps PRKAR1, anticorps TSE1, anticorps 1300018C22Rik, anticorps RIalpha, anticorps Tse-1, anticorps Tse1, anticorps RIIA, anticorps prkar1a, anticorps zgc:92515, anticorps im:7047729, anticorps cnc1, anticorps pkr1, anticorps ppnad1, anticorps prkar1, anticorps tse1, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha, anticorps protein kinase, cAMP dependent regulatory, type I, alpha, anticorps protein kinase cAMP-dependent type 1 regulatory subunit alpha, anticorps protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a, anticorps cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog, anticorps PRKAR1A, anticorps Prkar1a, anticorps prkar1aa, anticorps LOC707275, anticorps prkar1a.S
Sujet
The prokineticin receptors, PKR1 (GPR73a) and PKR2 (GPR73b), are G proteincoupled receptors responsible for mediating the signal transduction of both EG-VEGF and Prokineticin-2. PKR1 and PKR2 share 87 % sequence identity. PKR1 is predominantly expressed in the peripheral tissues and PKR2 is typically expressed in the CNS. Both receptors are found in the testis. Upon ligand binding, PKR1 and PKR2 associate with G protein and can promote intracellular calcium mobilization, stimulate phosphoinositide turnover and activate the MAPK pathway. These receptors play a role in a variety of physiological events such as intestinal contraction, ingestive behavior, spermatogenesis, angiogenesis, circadian rhythm, neuronal survival and hyperalgesia. PKR1 may promote cardiomyocyte survival. PKR2 is essential for the normal development of the olfactory bulb. Mutations in the gene encoding PKR2 may result in Kallmann syndrome type 3.Synonyms: CAR, CNC1, PKR1, PRKAR1, TSE1, Tissue-specific extinguisher 1, cAMP-dependent protein kinase type I-alpha regulatory subunit