FDFT1 anticorps (Farnesyl-Diphosphate Farnesyltransferase 1) (N-Term)

Details for Product anti-FDFT1 Antibody No. ABIN357711, Fournisseur: Connectez-vous pour afficher
Antigène
  • FDFT1
  • DKFZp459C1712
  • SQS
  • SS
  • DGPT
  • ERG9
  • fdft1
  • farnesyl-diphosphate farnesyltransferase 1
  • squalene synthase
  • farnesyl diphosphate farnesyl transferase 1
  • FDFT1
  • fdft1
  • LOC100560926
  • Fdft1
Épitope
N-Term
12
11
11
10
10
9
7
7
7
5
5
5
4
4
2
1
1
Reactivité
Humain, Souris
108
32
16
4
3
2
2
2
2
1
1
1
Hôte
Lapin
103
17
Clonalité
Polyclonal
Conjugué
Cet anticorp FDFT1 est non-conjugé
11
11
7
6
6
6
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
116
65
60
14
14
9
7
6
4
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human FDFT1.
Isotype Ig Fraction
Specificité This antibody detects FDFT1 (N-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Plasmids, Primers & others Plasmids, Primers & others FDFT1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Squalene Synthetase (FDFT1 Antibody Extrait)
Sujet FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.Synonyms: FDFT1, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, SQS, SS
Poids moléculaire 48115 Da
ID gène 2222, 5874
UniProt P37268
Pathways Regulation of Lipid Metabolism by PPARalpha
Indications d'application ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Images (Fournisseur)
 image for anti-Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) (N-Term) antibody (ABIN357711) anti-Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) (N-Term) antibody
 image for anti-Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) (N-Term) antibody (ABIN357711) anti-Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1) (N-Term) antibody (Image 2)
Background publications Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Soltis, McMahon, Caplan, Dudas, Chamberlin, Vattay, Dottavio, Rucker, Engstrom, Cornell-Kennon: "Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems." dans: Archives of biochemistry and biophysics, Vol. 316, Issue 2, pp. 713-23, 1995 (PubMed).

Summers, Karst, Charles: "Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase." dans: Gene, Vol. 136, Issue 1-2Che, pp. 185-92, 1994 (PubMed).

Jiang, McKenzie, Conrad, Shechter: "Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase." dans: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12818-24, 1993 (PubMed).

Robinson, Tsay, Kienzle, Smith-Monroy, Bishop: "Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation." dans: Molecular and cellular biology, Vol. 13, Issue 5, pp. 2706-17, 1993 (PubMed).

Zinkl, Roberts, Shea, Lasmanis: "Toxicity of acephate and methamidophos to dark-eyed juncos." dans: Archives of environmental contamination and toxicology, Vol. 10, Issue 2, pp. 185-92, 1981 (PubMed).

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