MSK1 anticorps (AA 374-378)
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- Antigène Voir toutes MSK1 (RPS6KA5) Anticorps
- MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
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Épitope
- AA 374-378
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MSK1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous level of total MSK1 protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Peptide sequence around AA 374-378 (G-Y-S-F-V) derived from Human MSK1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotype
- IgG
- Top Product
- Discover our top product RPS6KA5 Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
- Autre désignation
- MSK1 (RPS6KA5 Produits)
- Synonymes
- anticorps MSK1, anticorps MSPK1, anticorps RLPK, anticorps 3110005L17Rik, anticorps 6330404E13Rik, anticorps AI854034, anticorps Msk1, anticorps ribosomal protein S6 kinase A5, anticorps ribosomal protein S6 kinase, polypeptide 5, anticorps RPS6KA5, anticorps Rps6ka5
- Sujet
- Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
- Poids moléculaire
- 90 kDa
- NCBI Accession
- NP_004746
- UniProt
- O75582
- Pathways
- Signalisation MAPK, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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