NPM1 anticorps (C-Term)
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- Antigène Voir toutes NPM1 Anticorps
- NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Chimpanzé
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NPM1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Séquence
- C-QEAIQDLWQW RKSL
- Specificité
- This antibody recognizes Nucleophosmin.
- Réactivité croisée (Details)
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Species reactivity (expected):Canine, Bovine.
Species reactivity (tested):Human, Mouse, Rat. - Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- Immunogène
- Peptide with sequence from the C Terminus of the protein sequence according to NP_002511.1, NP_954654.1.
- Top Product
- Discover our top product NPM1 Anticorps primaire
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- Indications d'application
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Peptide ELISA: 1/2000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3 containing 0.02 % Sodium Azide and 0.5 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))
- Autre désignation
- Nucleophosmin (NPM1 Produits)
- Synonymes
- anticorps B23, anticorps NPM, anticorps NO38, anticorps Npm, anticorps B23NP, anticorps npm4, anticorps npm, anticorps CG7917, anticorps CRP1, anticorps Crp1, anticorps Dmel\\CG7917, anticorps dNLP, anticorps dNLP-S, anticorps p22, anticorps npm1, anticorps sb:cb487, anticorps nucleophosmin 1, anticorps nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog, anticorps nucleophosmin 1b, anticorps Nucleophosmin, anticorps nucleophosmin, anticorps nucleophosmin (nucleolar phosphoprotein B23, numatrin), anticorps Nucleoplasmin, anticorps nucleophosmin 1a, anticorps NPM1, anticorps Npm1, anticorps npm1.L, anticorps npm1b, anticorps npm, anticorps Nlp, anticorps npm1a
- Sujet
- Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.Synonyms: NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin
- ID gène
- 4869
- NCBI Accession
- NP_002511
- UniProt
- P06748
- Pathways
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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