Angiotensin II Type-1 Receptor anticorps (Internal Region)

N° du produit ABIN374853

Détail du produit anti-Angiotensin II Type-1 Receptor anticorps

Antigène: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiotensin II Type-1 Receptor est non-conjugé

Application: Western Blotting (WB)

Séquence: C-EIQKNKPRND DIFK

Specificité: This antibody recognizes AGTR1 / AT1.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1, NP_114438.1.

Information d'application

Indications d'application: Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Angiotensin II Type-1 Receptor

Antigène: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Autre désignation: Type-1 Angiotensin II Receptor (AT1) (AGTR1 Produits)

Synonymes: anticorps AG2S, anticorps AGTR1A, anticorps AGTR1B, anticorps AT1, anticorps AT1AR, anticorps AT1B, anticorps AT1BR, anticorps AT1R, anticorps AT2R1, anticorps AT2R1A, anticorps AT2R1B, anticorps HAT1R, anticorps 1810074K20Rik, anticorps AI551199, anticorps AT1a, anticorps Agtr-1a, anticorps Agtr1, anticorps Angtr-1a, anticorps AT1A, anticorps XAT-1, anticorps agtr1-A, anticorps agtr1.2, anticorps AT1-R, anticorps at1, anticorps AGTR1, anticorps Agtr-1b, anticorps Angtr-1b, anticorps agtr1, anticorps agtr1-a, anticorps agtr1-b, anticorps xAT, anticorps angiotensin II receptor type 1, anticorps angiotensin II receptor, type 1a, anticorps angiotensin II receptor type 1 S homeolog, anticorps uncharacterized AGTR1, anticorps angiotensin II receptor, type 1b, anticorps angiotensin II receptor type 1 L homeolog, anticorps AGTR1, anticorps Agtr1a, anticorps agtr1.S, anticorps Agtr1, anticorps Agtr1b, anticorps agtr1.L

Sujet: Type 1 Angiotensin Receptors (AT1A and AT1B) mediate the major cardiovascular effects of angiotensin II, controlling blood pressure and volume by regulating cell growth, vascular contraction, inflammatory responses, and salt and water retention. Stimulation of AT1 receptors by Ang II activates phospholipase C beta, resulting in increased intracellular calcium and inositol 1, 4, 5-triphosphate concentrations, and activatesthe mitogen-activated protein kinases, such as extracellular regulated kinases, by way of Src and Ras as well as the JAK/STAT pathways. AT1 knock-out mice have lower blood pressure than wild type mice and lose normal pressor response to exogenous Ang II. AT1B differs from AT1A in its mRNA tissue distribution and in the 5' untranslated region. AT1 blockers have become widely used in the treatment of hypertension and may offer benefits other than blood pressure reduction.Synonyms: AGTR1, AGTR1A, AGTR1B, AT1AR, AT1BR, AT2R1, AT2R1B

ID gène: 185, 9606

UniProt: P30556

Pathways: Signalistation JAK/STAT, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour