NR1I2 anticorps (all Isoforms, Internal Region)

N° du produit ABIN375099

Détail du produit anti-NR1I2 anticorps

Antigène: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Épitope: all Isoforms, Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp NR1I2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognizes PXR / NR1I2. It is expected to recognize all reported isoforms (NP_071285.1, NP_148934.1, NP_003880.3).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence EQFAITLKSYIECNR, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/4000. Western Blot: 1-3 μg/mL. An additional band of unknown identity was also consistentlyobserved at 35 kDa. This band was successfully blocked by incubation with the immunizingpeptide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NR1I2

Antigène: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Autre désignation: NR1I2 (NR1I2 Produits)

Synonymes: anticorps BXR, anticorps ONR1, anticorps PAR, anticorps PAR1, anticorps PAR2, anticorps PARq, anticorps PRR, anticorps PXR, anticorps SAR, anticorps SXR, anticorps PXR.1, anticorps PXR.2, anticorps PXR1, anticorps mPXR, anticorps bxr, anticorps nr1i2, anticorps onr1, anticorps xonr1, anticorps nuclear receptor subfamily 1 group I member 2, anticorps nuclear receptor subfamily 1, group I, member 2, anticorps nuclear receptor subfamily 1 group I member 2 S homeolog, anticorps NR1I2, anticorps Nr1i2, anticorps nr1i2.S, anticorps nr1i2

Sujet: The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine, transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues.Synonyms: Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, PXR, Pregnane X receptor, Steroid and xenobiotic receptor

ID gène: 8856, 9606

UniProt: O75469

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway