IFT57 anticorps (Internal Region)

N° du produit ABIN375157

Détail du produit anti-IFT57 anticorps

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IFT57 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to HIPPI.

Réactivité croisée (Details): Species reactivity (expected):Rat, Bovine.
Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-EQPQEYDDPNATISN, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur IFT57

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Autre désignation: HIP1-Interacting Protein (IFT57 Produits)

Synonymes: anticorps Esrrbl1, anticorps 4833420A15Rik, anticorps Hippi, anticorps MHS4R2, anticorps ESRRBL1, anticorps HIPPI, anticorps intraflagellar transport 57, anticorps intraflagellar transport 57 S homeolog, anticorps Ift57, anticorps IFT57, anticorps ift57.S

Sujet: HIPPI was identified as a protein that interacts with HIP1 (Huntingtin-interacting protein 1). HIPPI mRNA is expressed in the brain. It is present in all regions of the brain, and to a lesser extent in spinal cord. It is also expressed abundantly in heart, kidney, and lung, with weaker expression in all other tissues tested. HIPPI is expressed in the Golgi apparatus of neurons where it partly colocalizes with HIP1. HIPPI forms a heterodimer with HIP1. The availability of free HIP1 is modulated by polyglutamine length within huntingtin, with disease-associated polyglutamine expansion favoring the formation of proapoptotic HIPPI-HIP1 heterodimers. These heterodimers can recruit procaspase-8 into a complex of HIPPI, HIP1, and procaspase-8 and launch apoptosis through components of the extrinsic cell death pathway. This novel non-receptor-mediated pathway for activating caspase-8 might contribute to neuronal death in Huntington disease.Synonyms: DERP8, Dermal papilla-derived protein 8, ESRRBL1, Estrogen-related receptor beta-like protein 1, HIPPI, IFT57, Intraflagellar transport protein 57 homolog, MHS4R2

ID gène: 55081, 9606

UniProt: Q9NWB7

Pathways: Signalisation Hedgehog, Positive Regulation of Endopeptidase Activity