MKNK1 anticorps (N-Term)

N° du produit ABIN391226

Détail du produit anti-MKNK1 anticorps

Antigène: MKNK1 (MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKNK1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MKNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1.

Clone: RB8561

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur MKNK1

Antigène: MKNK1 (MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1))

Autre désignation: MKNK1 (MKNK1 Produits)

Synonymes: anticorps MNK1, anticorps MKNK1, anticorps zgc:171912, anticorps 2410048M24Rik, anticorps Mnk1, anticorps MAPK signal-integrating kinase 1, anticorps mknk1, anticorps mnk1, anticorps MAP kinase interacting serine/threonine kinase 1, anticorps MAP kinase-interacting serine/threonine kinase 1, anticorps MAP kinase interacting serine/threonine kinase 1 S homeolog, anticorps MKNK1, anticorps mknk1, anticorps Mknk1, anticorps mknk1.S

Sujet: MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.

Poids moléculaire: 51342

ID gène: 8569

NCBI Accession: NP_001129025, NP_003675, NP_945324

UniProt: Q9BUB5

Pathways: Signalisation MAPK, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor