TAF1 anticorps (C-Term)

N° du produit ABIN401389

Détail du produit anti-TAF1 anticorps

Antigène: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAF1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against TAF1 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to amino acids near the carboxyl terminus of human TAF1

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/10,000 - 1/50,000. Western Blot: 1/100 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.15 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur TAF1

Antigène: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Autre désignation: TAF1 (TAF1 Produits)

Synonymes: anticorps BG:DS00004.13, anticorps CG17603, anticorps Dmel\\CG17603, anticorps EfW1, anticorps SR3-5, anticorps TAF, anticorps TAF1, anticorps TAF200, anticorps TAF230, anticorps TAF250, anticorps TAF250/230, anticorps TAFII-250, anticorps TAFII250, anticorps TAF[II]250, anticorps TAF[[II]], anticorps TAF[[II]]230, anticorps TAF[[II]]250, anticorps TAF[[II]]250/230, anticorps TFIID, anticorps TFIID TAF250, anticorps Taf1p, anticorps Taf200, anticorps Taf230, anticorps Taf250, anticorps Taf[[II]]250, anticorps cel, anticorps cell, anticorps d230, anticorps dTAF230, anticorps dTAF250, anticorps dTAFII250, anticorps dTAF[[II]]230, anticorps dTAF[[II]]250, anticorps dmTAF1, anticorps dmTAF[[II]]230, anticorps l(3)84Ab, anticorps p230, anticorps 250kDa, anticorps AU015687, anticorps B430306D02Rik, anticorps Ccg-1, anticorps Ccg1, anticorps KAT4, anticorps N-TAF1, anticorps Taf2a, anticorps RGD1562050, anticorps BA2R, anticorps CCG1, anticorps CCGS, anticorps DYT3, anticorps DYT3/TAF1, anticorps NSCL2, anticorps OF, anticorps P250, anticorps TAF2A, anticorps XDP, anticorps TAF(II)250, anticorps p250, anticorps TBP-associated factor 1, anticorps TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa, anticorps transcription initiation factor TFIID subunit 1, anticorps transcription initiation factor TFIID, subunit TAF1, anticorps TATA-box binding protein associated factor 1, anticorps Taf1, anticorps TAF1, anticorps LOC5567420, anticorps CpipJ_CPIJ003658, anticorps TAF11.1, anticorps HAF1501, anticorps HAF1502, anticorps LOC100457071

Sujet: Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex, which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors. TFIID nucleates the formation of transcription preinitiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II. TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors. For example, TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue, leading to MDM2-mediated degradation of TP53. TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1). The retinoblastoma tumor suppressor protein, RB1, interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity. TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18 % of mammalian genes.Synonyms: BA2R, CCG1, CCGS, Cell cycle gene 1 protein, TAFII250, TBP-associated factor 250 kDa, Transcription initiation factor TFIID 250 kDa subunit, Transcription initiation factor TFIID subunit 1

ID gène: 6872

NCBI Accession: NP_004597

UniProt: P21675