CD19 anticorps (PE)
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- Antigène Voir toutes CD19 Anticorps
- CD19 (CD19 Molecule (CD19))
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD19 est conjugé à/à la PE
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Application
- Flow Cytometry (FACS)
- Specificité
- The rat monoclonal antibody 1D3 detects an extracellular epitope of murine CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.
- Réactivité croisée (Details)
- Mouse
- Purification
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Mouse CD19-transfected cell line
- Clone
- 1D3
- Isotype
- IgG2a
- Top Product
- Discover our top product CD19 Anticorps primaire
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- Indications d'application
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
- Commentaires
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 8, pp. 4062-72, (2003) (PubMed).
: "Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement." dans: Blood, Vol. 99, Issue 2, pp. 584-9, (2002) (PubMed).
: "The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 163-72, (2001) (PubMed).
: "Self-renewal of B-1 lymphocytes is dependent on CD19." dans: European journal of immunology, Vol. 26, Issue 1, pp. 238-42, (1996) (PubMed).
: "The signaling activity of murine CD19 is regulated during cell development." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 1, pp. 48-56, (1996) (PubMed).
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The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 8, pp. 4062-72, (2003) (PubMed).
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- Antigène
- CD19 (CD19 Molecule (CD19))
- Autre désignation
- CD19 (CD19 Produits)
- Synonymes
- anticorps B4, anticorps CVID3, anticorps AW495831, anticorps CD19, anticorps CD19 molecule, anticorps CD19 antigen, anticorps CD19, anticorps Cd19
- Sujet
- CD19 Molecule,CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.,B4, Leu-12, Cvid
- ID gène
- 12478
- UniProt
- P25918
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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