FURIN anticorps

N° du produit ABIN4903706

Détail du produit anti-FURIN anticorps

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FURIN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

Purification: Affinity purification

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur FURIN

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Autre désignation: FURIN (FURIN Produits)

Synonymes: anticorps FURIN, anticorps furin, anticorps si:dkey-281a24.5, anticorps FUR, anticorps LOC100220259, anticorps PACE, anticorps spc1, anticorps xfurin, anticorps MGC82710, anticorps PCSK3, anticorps SPC1, anticorps 9130404I01Rik, anticorps Fur, anticorps Pcsk3, anticorps Pace, anticorps furin, paired basic amino acid cleaving enzyme, anticorps furin (paired basic amino acid cleaving enzyme) a, anticorps furin (paired basic amino acid cleaving enzyme) b, anticorps furin, paired basic amino acid cleaving enzyme L homeolog, anticorps furin (paired basic amino acid cleaving enzyme), anticorps FURIN, anticorps furina, anticorps furinb, anticorps furin, anticorps furin.L, anticorps Furin

ID gène: 5045

UniProt: P09958

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway