HLA-C anticorps

N° du produit ABIN4903930

Détail du produit anti-HLA-C anticorps

Antigène: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-C est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Purification: Affinity purification

Immunogène: Recombinant protein of human HLA-C.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur HLA-C

Antigène: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Autre désignation: HLA-C (HLA-C Produits)

Synonymes: anticorps D6S204, anticorps HLA-JY3, anticorps HLC-C, anticorps PSORS1, anticorps major histocompatibility complex, class I, C, anticorps HLA-C

ID gène: 3107

UniProt: P30499

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process