Complement Factor I anticorps

N° du produit ABIN4955823

Détail du produit anti-Complement Factor I anticorps

Antigène: Complement Factor I (CFI)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement Factor I est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: Antigen affinity

Immunogène: Amino acids K19-D220 were used as the immunogen for the Factor I antibody.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 0.1-0.5 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Factor I antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Complement Factor I

Antigène: Complement Factor I (CFI)

Autre désignation: Complement Factor I / CFI (CFI Produits)

Synonymes: anticorps cfi, anticorps MGC53615, anticorps Cfi, anticorps factor I, anticorps IF, anticorps gb:ai721528, anticorps ahus3, anticorps c3b-ina, anticorps c3bc4bi, anticorps c3bina, anticorps kaf, anticorps CFI, anticorps AHUS3, anticorps C3BINA, anticorps C3b-INA, anticorps FI, anticorps KAF, anticorps complement factor I S homeolog, anticorps complement factor I L homeolog, anticorps complement factor I, anticorps complement component factor i, anticorps cfi.S, anticorps cfi.L, anticorps CFI, anticorps cfi, anticorps Cfi

Sujet: Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

UniProt: P05156

Pathways: Système du Complément