MYBL2 anticorps

N° du produit ABIN498105

Détail du produit anti-MYBL2 anticorps

Antigène: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYBL2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody antibody detects endogenous levels of B-Myb / MYB2 protein.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: Western Blots: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MYBL2

Antigène: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Autre désignation: MYBL2 (MYBL2 Produits)

Synonymes: anticorps MYBL2, anticorps bmyb, anticorps b-myb, anticorps B-Myb, anticorps Bmyb, anticorps B-MYB, anticorps BMYB, anticorps myb1, anticorps MYB proto-oncogene like 2, anticorps v-myb avian myeloblastosis viral oncogene homolog-like 2b, anticorps myeloblastosis oncogene-like 2, anticorps MYB proto-oncogene like 2 S homeolog, anticorps MYBL2, anticorps mybl2, anticorps mybl2b, anticorps Mybl2, anticorps mybl2.S

Sujet: Expression of the B-Myb transcription factor is upregulated during late G1 phase of the cell cycle by an E2F-dependent transcriptional mechanism. B-Myb is specifically phosphorylated during S phase, suggesting that a cyclin-dependent kinase (Cdk) regulates its activity. Consistent with this notion, the S phase-specific cyclin A/Cdk2 was found previously to enhance B-Myb transactivation activity in cotransfected cells. There is evidence that B-Myb is a direct physiological target for cyclin A/Cdk2. Data indicate that phosphorylation by cyclin A/Cdk2 is directly involved in enhancing B-Myb transactivation activity and that levels of endogenous cyclin A/Cdk2 activity may contribute to cell line-specific B-Myb function . Nuclear entry of B-Myb is dependent on multiple nuclear localization signals (NLS's). Mutagenesis of the putative NLS's of B-Myb has identified two separate NLS's, NLS1 and NLS2. Each of the two NLS's is essential for efficient nuclear targeting.Synonyms: B-Myb, BMYB, Myb-like protein 2, Myb-related protein B

Poids moléculaire: approx. 80 kDa

ID gène: 4605

NCBI Accession: NP_002457

UniProt: P10244

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Chromatin Binding