SKP1 anticorps

N° du produit ABIN498169

Détail du produit anti-SKP1 anticorps

Antigène: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Skp1 p19 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur SKP1

Antigène: SKP1 (S-Phase Kinase-Associated Protein 1 (SKP1))

Autre désignation: SKP1 / OCP2 (SKP1 Produits)

Synonymes: anticorps EMC19, anticorps OCP-II, anticorps OCP2, anticorps SKP1A, anticorps TCEB1L, anticorps p19A, anticorps 15kDa, anticorps 2610043E24Rik, anticorps 2610206H23Rik, anticorps SKP1, anticorps Tceb1l, anticorps p19Skp1, anticorps Skp1a, anticorps skp1a, anticorps zgc:73186, anticorps ocp2, anticorps emc19, anticorps ocp-ii, anticorps tceb1l, anticorps ARABIDOPSIS SKP1 HOMOLOGUE 1, anticorps ASK1, anticorps ATSKP1, anticorps S phase kinase-associated protein 1, anticorps T4O12.17, anticorps T4O12_17, anticorps UFO INTERACTING PROTEIN 1, anticorps UIP1, anticorps ocp-2, anticorps S-phase kinase associated protein 1, anticorps S-phase kinase-associated protein 1, anticorps S-phase kinase-associated protein 1 pseudogene, anticorps S-phase kinase-associated protein 1A, anticorps S-phase kinase-associated protein 1 S homeolog, anticorps S phase kinase-associated protein 1, anticorps SKP1, anticorps skp1, anticorps LOC100340043, anticorps Skp1a, anticorps Skp1, anticorps skp1.S

Sujet: The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.Synonyms: Cyclin A/CDK2-associated protein p19, EMC19, OCP-2, OCP-II, Organ of Corti protein 2, RNA polymerase II elongation factor-like protein, S-phase kinase-associated protein 1, SKP1A, TCEB1L, Transcription elongation factor B, p19A, p19skp1

Poids moléculaire: approx. 19 kDa

ID gène: 6500

NCBI Accession: NP_008861

UniProt: P63208

Pathways: Cycle Cellulaire, Signalisation Hedgehog, Mitotic G1-G1/S Phases