STAM2 anticorps

N° du produit ABIN498238

Détail du produit anti-STAM2 anticorps

Antigène: STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAM2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of STAM2 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur STAM2

Antigène: STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2))

Autre désignation: STAM2 (STAM2 Produits)

Synonymes: anticorps Hbp, anticorps STAM2A, anticorps STAM2B, anticorps 1200004O12Rik, anticorps 5730456G07Rik, anticorps BB145015, anticorps stam2, anticorps MGC52950, anticorps zgc:103628, anticorps signal transducing adaptor molecule 2, anticorps signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, anticorps signal transducing adaptor molecule 2 S homeolog, anticorps STAM2, anticorps Stam2, anticorps stam2.S, anticorps stam2

Sujet: Cytokine stimulation of the IL-2 receptor leads to the tyrosine phosphorylation of a number of cellular proteins and to the induction of various transcription factors including c-Fos and c-Myc. The signal transducing adapter molecule, STAM, is speculated to play a role in c-Myc induction by various cytokines. STAM contains an SH3 (Src homology 3) motif as well as an immunoreceptor tyrosine-based activation (ITAM) motif, both of which appear to be required for c-Myc induction in response to IL-2 and GM-CSF. STAM associates with JAK3 and JAK2 via its ITAM region, and it is tyrosine phosphorylated by JAK3 and JAK2 after stimulation with IL-2 and GM-CSF, respectively. STAM2, also known as Hbp, is a protein that is highly related to STAM. Similar to STAM, STAM2 functions downstream of JAK kinases and can be phosphorylated in response to cytokines. Due to alternative splicing events, two isoforms of STAM2 exist, namely STAM2A and STAM2B.Synonyms: HBP, Hrs-binding protein, STAM-2, STAM2A, STAM2B, Signal transducing adapter molecule 2

Poids moléculaire: approx. 58 kDa

ID gène: 10254

NCBI Accession: NP_005834

UniProt: O75886

Pathways: EGFR Signaling Pathway, EGFR Downregulation