Nibrin anticorps
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- Antigène Voir toutes Nibrin (NBN) Anticorps
- Nibrin (NBN)
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Nibrin est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificité
- This antibody detects endogenous levels of NBS1 protein. (region surrounding Gly274)
- Réactivité croisée (Details)
- Species reactivity (tested):Human.
- Purification
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product NBN Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Nibrin (NBN)
- Autre désignation
- Nibrin (NBN Produits)
- Synonymes
- anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn
- Sujet
- The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex (MRN complex). This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. NBS1 is expressed ubiquitously and presents high levels in testis.Synonyms: Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nijmegen breakage syndrome protein 1, P95
- Poids moléculaire
- approx. 95 kDa
- ID gène
- 4683
- NCBI Accession
- NP_002476
- UniProt
- O60934
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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