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Tuberin anticorps (pSer1254)
TSC2
Reactivité: Humain
IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-Tuberin anticorps
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Antigène
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Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Épitope
Tous les épitopes à travers Tuberin Anticorps.
pSer1254
Reactivité
Toutes les réactivités sur Tuberin Anticorps
Humain
Hôte
Toutes les hôtes sur Tuberin Anticorps
Lapin
Clonalité
Toutes les clonalités sur Tuberin Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers Tuberin Anticorps
Cet anticorp Tuberin est non-conjugé
Application
Tous les applications à travers Tuberin Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody detects endogenous levels of p-Tsc2 protein only when phosphorylated at Ser1254.
Réactivité croisée (Details)
Species reactivity (tested):Human.
Purification
Affinity chromatography
Pureté
> 95 % by SDS-PAGE
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Information d'application
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Indications d'application
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur Tuberin
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Antigène
Tuberin (TSC2)
(Tuberous Sclerosis 2 (TSC2))
Autre désignation
Tuberin / TSC2 (TSC2 Produits )
Synonymes
anticorps TSC2, anticorps fc16b02, anticorps tuberin, anticorps wu:fc16b02, anticorps LAM, anticorps TSC4, anticorps Nafld, anticorps Tcs2, anticorps Rc, anticorps TSC complex subunit 2, anticorps tuberin, anticorps hypothetical protein, anticorps tuberous sclerosis 2, anticorps TSC2, anticorps LOC5569538, anticorps tsc2, anticorps PGTG_00159, anticorps Tsc2
Sujet
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
Poids moléculaire
approx. 200 kDa
ID gène
7249
NCBI Accession
NP_000539
UniProt
P49815
Pathways
Signalisation RTK , AMPK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of Cell Size , Tube Formation , Protein targeting to Nucleus
Vus récemment
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