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eIF4EBP1 anticorps
EIF4EBP1
Reactivité: Humain, Souris, Rat
IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-eIF4EBP1 anticorps
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Antigène
Voir toutes eIF4EBP1 (EIF4EBP1) Anticorps
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Reactivité
Toutes les réactivités sur eIF4EBP1 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur eIF4EBP1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur eIF4EBP1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers eIF4EBP1 Anticorps
Cet anticorp eIF4EBP1 est non-conjugé
Application
Tous les applications à travers eIF4EBP1 Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody detects endogenous levels of 4E-BP1 protein. (region surrounding Pro71)
Réactivité croisée (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Pureté
> 95 % (by SDS-PAGE)
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Alternatives
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Information d'application
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Indications d'application
Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Détails sur eIF4EBP1
(cache)
Antigène
eIF4EBP1 (EIF4EBP1)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
Autre désignation
EIF4EBP1 / 4E-BP1 (EIF4EBP1 Produits )
Synonymes
anticorps 4E-BP1, anticorps 4EBP1, anticorps BP-1, anticorps PHAS-I, anticorps 4e-bp1, anticorps AA959816, anticorps 153432_at, anticorps 43-BP, anticorps 4E-BP, anticorps 4EBP, anticorps 4e-bp, anticorps 4eBP, anticorps 4ebp, anticorps BcDNA.HL08053, anticorps BcDNA:HL08053, anticorps CG8846, anticorps CT8705, anticorps Dm 4E-BP, anticorps Dmel\\CG8846, anticorps Phas1, anticorps Thor/EIF4EBP, anticorps anon-WO0172774.158, anticorps d4E-BP, anticorps d4E-BP1, anticorps d4EBP, anticorps d4e-bp, anticorps d4eBP, anticorps dthor, anticorps eIF4E-BP, anticorps l(2)06270, anticorps l(2)k07736, anticorps l(2)k13517, anticorps pp20, anticorps thor, anticorps EIF4EBP1, anticorps fc04h09, anticorps wu:fc04h09, anticorps zgc:64137, anticorps eukaryotic translation initiation factor 4E binding protein 1, anticorps CG8846 gene product from transcript CG8846-RA, anticorps EIF4EBP1, anticorps Eif4ebp1, anticorps Thor, anticorps eif4ebp1
Sujet
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.Synonyms: Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-1, PHAS-I, PHAS1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, eIF4E-binding protein 1
Poids moléculaire
approx. 15 to 20 kDa
ID gène
1978
NCBI Accession
NP_004086
UniProt
Q13541
Pathways
Signalisation MAPK , Signalisation PI3K-Akt , Signalisation RTK , AMPK Signaling , Regulation of Cell Size , BCR Signaling
Vus récemment
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