FGFR4 anticorps (AA 1-100) (AbBy Fluor® 680)
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- Antigène Voir toutes FGFR4 Anticorps
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
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Épitope
- AA 1-100
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FGFR4 est conjugé à/à la AbBy Fluor® 680
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Rat
- Homologie
- Mouse,Dog
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human FGFR4
- Isotype
- IgG
- Top Product
- Discover our top product FGFR4 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Autre désignation
- FGFR4/CD334 (FGFR4 Produits)
- Synonymes
- anticorps FGFR4, anticorps XFGFR-4, anticorps XFGFR-4a, anticorps cd334, anticorps fgfr-4, anticorps jtk2, anticorps tkf, anticorps xfgfr4, anticorps CD334, anticorps JTK2, anticorps TKF, anticorps Fgfr-4, anticorps etID309818.21, anticorps wu:fc13h10, anticorps zgc:111935, anticorps fgfr-4c, anticorps fgfr4, anticorps fibroblast growth factor receptor 4, anticorps fibroblast growth factor receptor 4 S homeolog, anticorps FGFR4, anticorps fgfr4, anticorps Fgfr4, anticorps fgfr4.S
- Sujet
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Synonyms: TKF, JTK2, CD334, Fibroblast growth factor receptor 4, FGFR-4, FGFR4
Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
- ID gène
- 2264
- UniProt
- P22455
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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