anticorps APG16L, anticorps ATG16A, anticorps ATG16L, anticorps IBD10, anticorps WDR30, anticorps 1500009K01Rik, anticorps Apg16l, anticorps Atg16l, anticorps Wdr30, anticorps atg16, anticorps atg16l, anticorps fb57e05, anticorps wu:fb57e05, anticorps zgc:110147, anticorps autophagy related 16 like 1, anticorps autophagy related 16-like 1 (S. cerevisiae), anticorps autophagy related 16-like 1, anticorps autophagy related 16 like 1 S homeolog, anticorps ATG16 autophagy related 16-like 1 (S. cerevisiae), anticorps ATG16L1, anticorps Atg16l1, anticorps atg16l1, anticorps atg16l1.S
Sujet
ATG16L1/APG16L is part of a large protein complex that functions as a molecular scaffold mediating protein-protein interactions necessary for formation of the autophagosome in response to both classical and pathogen-related autophagy stimuli. APG16L protein contains an N-terminal Atg5-binding domain, a coiled-coil domain and a C-terminal WD (tryptophan-aspartic acid)-repeat domain. APG16L forms a complex with the Atg12 Atg5 conjugate and together they are actively translocated to the phagophore and are further elongated during autophagosome formation. Genetic variation in the APG16L gene has been recently implicated in Crohn's disease pathogenesis. Polymorphism within APG16L gene results in excessive production of IL-1beta and IL-6 culmunating in the inflammatory process in Crohn's disease.