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CD73 anticorps (AA 145-346)

NT5E Reactivité: Humain WB, IHC Hôte: Souris Monoclonal ABM40E2 unconjugated
N° du produit ABIN5027099
  • Antigène Voir toutes CD73 (NT5E) Anticorps
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    Épitope
    • 16
    • 9
    • 9
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 145-346
    Reactivité
    • 106
    • 59
    • 27
    • 18
    • 18
    • 16
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 80
    • 38
    • 17
    • 2
    Souris
    Clonalité
    • 71
    • 66
    Monoclonal
    Conjugué
    • 59
    • 16
    • 12
    • 9
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD73 est non-conjugé
    Application
    • 83
    • 64
    • 50
    • 40
    • 17
    • 14
    • 14
    • 14
    • 13
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Protein G Chromatography
    Immunogène
    A partial length recombinant CD73 protein (amino acids 145-346) was used as the immunogen for this antibody.
    Clone
    ABM40E2
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product NT5E Anticorps primaire
  • Indications d'application
    WB: 2-4 μg/mL, IHC: 5 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.05 % BSA, PH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Antigène
    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))
    Autre désignation
    CD73 (NT5E Produits)
    Synonymes
    anticorps CALJA, anticorps CD73, anticorps E5NT, anticorps NT, anticorps NT5, anticorps NTE, anticorps eN, anticorps eNT, anticorps zgc:63784, anticorps NT5E, anticorps MGC114869, anticorps PSPTO2277, anticorps 2210401F01Rik, anticorps AI447961, anticorps Nt5, anticorps 5'-nucleotidase ecto, anticorps 5'-nucleotidase, ecto (CD73), anticorps 5'-nucleotidase, anticorps 5' nucleotidase, ecto, anticorps NT5E, anticorps nt5e, anticorps nt5e.S, anticorps PSPTO_2277, anticorps CBU_1233, anticorps MCA1322, anticorps Nt5e
    Sujet
    CD73, also known as ecto-5'-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.
    Poids moléculaire
    63 kDa
    ID gène
    4907
    UniProt
    P21589
    Pathways
    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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