FURIN anticorps (AA 602-791)

N° du produit ABIN5027211

Détail du produit anti-FURIN anticorps

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Épitope: AA 602-791

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FURIN est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant Furin protein (amino acids 602-791) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur FURIN

Antigène: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Autre désignation: Furin (FURIN Produits)

Synonymes: anticorps FURIN, anticorps furin, anticorps si:dkey-281a24.5, anticorps FUR, anticorps LOC100220259, anticorps PACE, anticorps spc1, anticorps xfurin, anticorps MGC82710, anticorps PCSK3, anticorps SPC1, anticorps 9130404I01Rik, anticorps Fur, anticorps Pcsk3, anticorps Pace, anticorps furin, paired basic amino acid cleaving enzyme, anticorps furin (paired basic amino acid cleaving enzyme) a, anticorps furin (paired basic amino acid cleaving enzyme) b, anticorps furin, paired basic amino acid cleaving enzyme L homeolog, anticorps furin (paired basic amino acid cleaving enzyme), anticorps FURIN, anticorps furina, anticorps furinb, anticorps furin, anticorps furin.L, anticorps Furin

Sujet: Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like endoproteinases. Furin along with PCs are intensively investigated as pharmacological targets for the treatment of many diseases, e.g., atherosclerosis, hypercholesterolaemia, and cancer, as well as viral and bacterial infections. Furin has been implicated in processing the Env (Envelope) proteins of human endogenous retroviruses, syncytins, the only possible fusogens known to be involved in placenta syncytialization, and therefore may participate in syncytin-mediated cell fusion in cells of both trophoblast and non-trophoblast lineages. Furin catalyzes proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive. Furin is highly expressed in EVTs (Extravillous CTBs) and that furin function is required for trophoblast cell invasion into the maternal endometrium.

Poids moléculaire: 97 kDa

ID gène: 5045

UniProt: P09958

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway