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PD-L1 anticorps (AA 13-224)
PD-L1
Reactivité: Humain
WB, FACS, IHC
Hôte: Souris
Monoclonal
ABM5F25
unconjugated
N° du produit ABIN5027498
Détail du produit anti-PD-L1 anticorps
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Antigène
Voir toutes PD-L1 Anticorps
PD-L1
(CD274 (PD-L1))
Épitope
Tous les épitopes à travers PD-L1 Anticorps.
AA 13-224
Reactivité
Toutes les réactivités sur PD-L1 Anticorps
Humain
Hôte
Toutes les hôtes sur PD-L1 Anticorps
Souris
Clonalité
Toutes les clonalités sur PD-L1 Anticorps
Monoclonal
Conjugué
Tous les conjugués à travers PD-L1 Anticorps
Cet anticorp PD-L1 est non-conjugé
Application
Tous les applications à travers PD-L1 Anticorps.
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Purification
Protein G Chromatography
Immunogène
A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.
Clone
ABM5F25
Isotype
IgG2b kappa
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Information d'application
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Indications d'application
FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL, IHC: 5-10 μg/mL
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Références pour anticorps anti-PD-L1 (ABIN5027498)
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Faruk, Ibrahim, Aminu, Adamu, Abdullahi, Suleiman, Rafindadi, Mohammed, Iliyasu, Idoko, Saidu, Randawa, Musa, Ntekim, Shah, Abubakar, Adoke, Manko, Awasum : "Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin. " dans: PLoS ONE , Vol. 16 , Issue 1 , pp. e0245581 , (2021 ) (PubMed ).
Détails sur PD-L1
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Antigène
PD-L1
(CD274 (PD-L1))
Autre désignation
PDL-1 (PD-L1 Produits )
Synonymes
anticorps B7-H, anticorps B7H1, anticorps PD-L1, anticorps PDCD1L1, anticorps PDCD1LG1, anticorps PDL1, anticorps A530045L16Rik, anticorps B7h1, anticorps Pdcd1l1, anticorps Pdcd1lg1, anticorps Pdl1, anticorps RGD1566211, anticorps CD274 molecule, anticorps CD274 antigen, anticorps programmed cell death 1 ligand 2, anticorps CD274, anticorps Cd274, anticorps PDCD1LG2
Sujet
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
Poids moléculaire
44 kDa
ID gène
29126
UniProt
Q9NZQ7
Pathways
Cancer Immune Checkpoints
Vus récemment
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