TBPL1 anticorps

N° du produit ABIN5027797

Détail du produit anti-TBPL1 anticorps

Antigène: TBPL1 (TBP-Like 1 (TBPL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TBPL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Chromatography

Immunogène: Full length recombinant TRF2 protein was used as the immunogen for this antibody.

Clone: ABM10H3

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur TBPL1

Antigène: TBPL1 (TBP-Like 1 (TBPL1))

Autre désignation: TRF2 (TBPL1 Produits)

Synonymes: anticorps MGC:8389, anticorps MGC:9620, anticorps STUD, anticorps TLF, anticorps TLP, anticorps TRF2, anticorps tlf, anticorps 4732475G08, anticorps AW011832, anticorps AW491032, anticorps D18347, anticorps STD, anticorps TRP, anticorps Tlp, anticorps tlp, anticorps trf, anticorps trf2, anticorps trp, anticorps zgc:92340, anticorps TATA binding protein 1, anticorps TFIID-1, anticorps TRANSCRIPTION FACTOR IID-1, anticorps TATA-box binding protein like 1, anticorps TATA-binding protein 1, anticorps TATA-box binding protein like 1 L homeolog, anticorps TATA box binding protein-like 1, anticorps TBP-like 1, anticorps TATA binding protein 1, anticorps TBPL1, anticorps tbp1, anticorps tbpl1.L, anticorps tbpl1, anticorps Tbpl1, anticorps TBP1

Sujet: TRF2 (Telomere Repeat Binding Factor 2), a subunit of the shelterin complex, binds to duplex telomeric DNA and plays a crucial role in telomere protection. TRF2 contains an N-terminal basic domain rich in glycines and arginines (the GAR domain), a central TRFH dimerization domain, a flexible linker region and a C-terminal Myb-like DNA binding domain. TRF2 undergoes extensive post-translational modification, which in turn regulates its stability, DNA binding and cellular localization. Ubiquitylation of TRF2 by Siah1, an E3 ligase, promotes TRF2 degradation and replicative senescence of human primary fibroblasts. TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair.

Poids moléculaire: 50 kDa

ID gène: 7014

UniProt: Q15554