TERT anticorps (Middle Region)

N° du produit ABIN5515584

Détail du produit anti-TERT anticorps

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TERT est non-conjugé

Application: Western Blotting (WB)

Séquence: RQHHAGPPST SRPPRPWDTP CPPVYAETKH FLYSSGDKEQ LRPSFLLSSL

Attributs du produit: This is a rabbit polyclonal antibody against TERT. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human TERT

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TERT

Antigène: TERT (Telomerase Reverse Transcriptase (TERT))

Autre désignation: TERT (TERT Produits)

Synonymes: anticorps CMM9, anticorps DKCA2, anticorps DKCB4, anticorps EST2, anticorps PFBMFT1, anticorps TCS1, anticorps TP2, anticorps TRT, anticorps hEST2, anticorps hTRT, anticorps chTERT, anticorps Tert, anticorps ATTERT, anticorps F5E19.190, anticorps F5E19_190, anticorps telomerase reverse transcriptase, anticorps tert, anticorps TR, anticorps est2, anticorps tcs1, anticorps telomerase, anticorps tert-A, anticorps tp2, anticorps trt, anticorps xTERT, anticorps telomerase reverse transcriptase, anticorps Telomerase Reverse Transcriptase, anticorps Tertp, anticorps Telomerase catalytic subunit, anticorps telomerase reverse transcriptase L homeolog, anticorps TERT, anticorps trt-1, anticorps Tert, anticorps tert, anticorps CMU_003490, anticorps VDBG_04487, anticorps GL50803_16225, anticorps tert.L

Sujet: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Alias Symbols: TERT, EST2, TCS1, TRT,

Protein Interaction Partner: TPP1, AKT1, HSP90AA1, HSPA4, DDX51, C19orf40, STEAP4, PBK, PHF20L1, TIMM21, PABPC1, SERBP1, SLC7A11, U2SURP, CCT5, ACAA2, TUBA1B, DYNLL1, UBE2D3, TGFBR2, PPIA, PFDN1, IREB2, GLA, ENO1, EIF2S1, ATP5B, ANXA2, CIB1, UBC, vpr, VPRBP, RUVBL2, RUVBL1, TERC, DKC

Protein Size: 807

ID gène: 7015

Pathways: Telomere Maintenance