PIP5K1A anticorps (Middle Region)

N° du produit ABIN5516131

Détail du produit anti-PIP5K1A anticorps

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIP5K1A est non-conjugé

Application: Western Blotting (WB)

Séquence: GGKNIRIVVM NNLLPRSVKM HIKYDLKGST YKRRASQKER EKPLPTFKDL

Attributs du produit: This is a rabbit polyclonal antibody against PIP5K1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human PIP5K1A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PIP5K1A

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Autre désignation: PIP5K1A (PIP5K1A Produits)

Synonymes: anticorps Pip5k1b, anticorps pip5k1c, anticorps PIP5K1A, anticorps pip5k1b, anticorps Pipk5a, anticorps Pipk5b, anticorps pip5k1a, anticorps zgc:110576, anticorps im:7140933, anticorps zgc:158838, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b, anticorps PIP5K1A, anticorps Pip5k1a, anticorps pip5k1a.L, anticorps pip5k1a, anticorps pip5k1aa, anticorps pip5k1ab

Sujet: PIP5K1A catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation.

Alias Symbols: Name=PIP5K1A,

Protein Interaction Partner: UBC, ITGB1BP2, HECW2, UBD, SIRT1, CSNK1A1, APP, PIP5KL1, CADPS, PLD2, PLD1, CASP3, TEC, ARF6, BTK, ARF5, ARF1,

Protein Size: 562

ID gène: 8394

UniProt: Q99755

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA