Phospholipase C gamma 1 anticorps (C-Term)

N° du produit ABIN5517384

Cet anticorps Lapin Polyclonal détecte spécifiquement Phospholipase C gamma 1 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin et Cobaye.

Aperçu rapide pour Phospholipase C gamma 1 anticorps (C-Term) (ABIN5517384)

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholipase C gamma 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Phospholipase C gamma 1 anticorps

Épitope: C-Term

Séquence: RGIVCPFVEI EVAGAEYDST KQKTEFVVDN GLNPVWPAKP FHFQISNPEF

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PLCG1. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLCG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Phospholipase C gamma 1

Antigène: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Autre désignation: PLCG1

Sujet: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: PLC1

Protein Interaction Partner: EGFR, UBC, SARNP, WDR61, RIC8A, AASDHPPT, UBR7, EHD4, DPP7, GTF3C4, LIMD1, RPL38, PYGB, ZAP70, KHDRBS1, RASA1, JAK2, JAK1, LCP2, ERBB3, ERBB2, CBL, LAT, VAV1, PDGFRB, INSR, IRS2, NTMT1, SPRY1, NPM1, NCAM1, ALK, PML, IBTK, EEF1A1, BLNK, BAG3, EPOR, CAMK2A,

Protein Size: 1290

ID gène: 5335

UniProt: P19174

Pathways: Signalisation RTK, Signalisation WNT, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling