B4GALT1 anticorps (C-Term)

N° du produit ABIN5517696

Détail du produit anti-B4GALT1 anticorps

Antigène: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp B4GALT1 est non-conjugé

Application: Western Blotting (WB)

Séquence: GRCRMIRHSR DKKNEPNPQR FDRIAHTKET MLSDGLNSLT YQVLDVQRYP

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human B4GALT1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur B4GALT1

Antigène: B4GALT1 (UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1))

Autre désignation: B4GALT1 (B4GALT1 Produits)

Synonymes: anticorps B4GAL-T1, anticorps CDG2D, anticorps GGTB2, anticorps GT1, anticorps GTB, anticorps beta4Gal-T1, anticorps B-1,4-GalT, anticorps B-1,4-GalT1, anticorps GalT, anticorps Ggtb, anticorps Ggtb2, anticorps b4Gal-T1, anticorps beta-1,4-GalT, anticorps beta-1,4-GalT1, anticorps beta-1,4-galactosyltransferase 1, anticorps UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, anticorps B4GALT1, anticorps B4galt1

Sujet: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose, all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.

Alias Symbols: GT1, GTB, CDG2D, GGTB2, B4GAL-T1, beta4Gal-T1,

Protein Size: 398

ID gène: 2683

NCBI Accession: NM_001497, NP_001488

UniProt: P15291

Pathways: Glycosaminoglycan Metabolic Process