SNRPN anticorps (N-Term)

N° du produit ABIN5517959

Détail du produit anti-SNRPN anticorps

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNRPN est non-conjugé

Application: Western Blotting (WB)

Séquence: MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF

Attributs du produit: This is a rabbit polyclonal antibody against SMN. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SMN

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SNRPN

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Autre désignation: SMN (SNRPN Produits)

Synonymes: anticorps SNRB', anticorps SNRPB', anticorps Snrpn, anticorps zgc:77315, anticorps HCERN3, anticorps PWCR, anticorps RT-LI, anticorps SM-D, anticorps SMN, anticorps SNRNP-N, anticorps SNURF-SNRPN, anticorps sm-N, anticorps 2410045I01Rik, anticorps Peg4, anticorps Pwcr1, anticorps FE 294, anticorps FE 294 psi, anticorps FE294, anticorps FE294 psi, anticorps SNURF, anticorps SNRPN, anticorps QflA-11237, anticorps QtrA-10022, anticorps Sm-N, anticorps SmN, anticorps snRNP-N, anticorps small nuclear ribonucleoprotein polypeptide-like, anticorps small nuclear ribonucleoprotein polypeptides B and B1, anticorps small nuclear ribonucleoprotein polypeptide N, anticorps small nuclear ribonucleoprotein N, anticorps small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51, anticorps SNRPN upstream reading frame, anticorps Small nuclear ribonucleoprotein-associated protein N, anticorps SNRPL, anticorps snrpb, anticorps SNRPN, anticorps Snrpn, anticorps snrpn, anticorps SNURF

Sujet: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.

Alias Symbols: SMN2, SMNC,

Protein Size: 294

ID gène: 6606

UniProt: Q16637