DKC1 anticorps (AA 185-213)

N° du produit ABIN5531012

Détail du produit anti-DKC1 anticorps

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Épitope: AA 185-213

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DKC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DKC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human DKC1.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For IF starting dilution is: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DKC1

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Autre désignation: DKC1 (DKC1 Produits)

Synonymes: anticorps CBF5, anticorps DKC, anticorps DKCX, anticorps NAP57, anticorps NOLA4, anticorps XAP101, anticorps dyskerin, anticorps fv62a07, anticorps wu:fa28f10, anticorps wu:fc87a02, anticorps wu:fi24a05, anticorps wu:fv62a07, anticorps zgc:110395, anticorps DKC1, anticorps cbf5, anticorps dkc, anticorps nap57, anticorps nola4, anticorps xap101, anticorps BC068171, anticorps Nap57, anticorps AtCBF5, anticorps AtNAP57, anticorps homologue of NAP57, anticorps dyskerin pseudouridine synthase 1, anticorps microRNA 664b, anticorps dyskeratosis congenita 1, dyskerin, anticorps dyskeratosis congenita 1, dyskerin L homeolog, anticorps homologue of NAP57, anticorps DKC1, anticorps MIR664B, anticorps dkc1, anticorps dkc1.L, anticorps Dkc1, anticorps NAP57

Sujet: DKC1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases.

Poids moléculaire: 58 kDa

ID gène: 1736

UniProt: O60832

Pathways: Telomere Maintenance