COPS7B anticorps (AA 223-257)

N° du produit ABIN5647523

Détail du produit anti-COPS7B anticorps

Antigène: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Épitope: AA 223-257

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS7B est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blot: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the COPS7B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur COPS7B

Antigène: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Autre désignation: COPS7B / CSN7b (COPS7B Produits)

Synonymes: anticorps MGC114836, anticorps D1Wsu66e, anticorps E130114M23, anticorps CSN7B, anticorps COP9 signalosome subunit 7B, anticorps COP9 signalosome subunit 7B S homeolog, anticorps Cops7b, anticorps COPS7B, anticorps cops7b.S

Sujet: COP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

ID gène: 64708

UniProt: Q9H9Q2

Pathways: Cycle Cellulaire