MAVS anticorps (AA 160-450)
-
- Antigène Voir toutes MAVS Anticorps
- MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
-
Épitope
- AA 160-450
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp MAVS est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Specificité
- Recognizes human Cardif.
- Pureté
- > 95% (SDS-PAGE)
- Immunogène
- Recombinant human Cardif (aa 160-450).
- Clone
- Adri-1
- Isotype
- IgG2b
- Top Product
- Discover our top product MAVS Anticorps primaire
-
-
- Indications d'application
- Immunocytochemistry: (1:100). Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western Blot: (1:1,000).
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Stable for at least 1 year after receipt when stored at -20°C.
-
- Antigène
- MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
- Autre désignation
- Cardif (MAVS Produits)
- Synonymes
- anticorps CARDIF, anticorps IPS-1, anticorps IPS1, anticorps VISA, anticorps D430028G21Rik, anticorps Visa, anticorps cardif, anticorps wu:fj20d04, anticorps zgc:158392, anticorps mitochondrial antiviral signaling protein, anticorps MAVS, anticorps Mavs, anticorps mavs
- Sujet
- RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.
- ID gène
- 57506
- NCBI Accession
- NP_065797
- UniProt
- Q7Z434
- Pathways
- Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
-