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RPS6KB1 anticorps (AA 422-426)
RPS6KB1
Reactivité: Humain
WB, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN5689319
Détail du produit anti-RPS6KB1 anticorps
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Antigène
Voir toutes RPS6KB1 Anticorps
RPS6KB1
(Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
Épitope
Tous les épitopes à travers RPS6KB1 Anticorps.
AA 422-426
Reactivité
Toutes les réactivités sur RPS6KB1 Anticorps
Humain
Hôte
Toutes les hôtes sur RPS6KB1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur RPS6KB1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers RPS6KB1 Anticorps
Cet anticorp RPS6KB1 est non-conjugé
Application
Tous les applications à travers RPS6KB1 Anticorps.
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Specificité
This antibody detects endogenous level of total p70 S6 Kinase protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogène
p70 S6 Kinase (Ab-424) antibody was raised against a peptide sequence around aa.422~426 (P-V-S-P-V) derived from Human p70S6k.
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Alternatives
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anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1) (pThr389), (pThr412) antibody
RPS6KB1
Reactivité: Humain, Souris, Rat, Porc
WB, IHC, ELISA, IF, ICC
Hôte: Lapin
Polyclonal
unconjugated
Information d'application
(cache)
Indications d'application
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Restrictions
For Research Use only
Stockage
(cache)
Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store antibody at -20°C for up to one year.
Détails sur RPS6KB1
(cache)
Antigène
RPS6KB1
(Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))
Autre désignation
p70 S6 Kinase (RPS6KB1 Produits )
Synonymes
anticorps PS6K, anticorps S6K, anticorps S6K-beta-1, anticorps S6K1, anticorps STK14A, anticorps p70 S6KA, anticorps p70(S6K)-alpha, anticorps p70-S6K, anticorps p70-alpha, anticorps 10539, anticorps 7084, anticorps CG10539, anticorps DS6K, anticorps Dmel\\CG10539, anticorps Dp70S6k, anticorps Dp70[s6k], anticorps Dp70s6k, anticorps S6k, anticorps dS6K, anticorps dS6k, anticorps dp70[S6k], anticorps dp70s6k, anticorps dps6k, anticorps ds6k, anticorps fs(3)07084, anticorps l(3)07084, anticorps p70 S6K, anticorps p70/S6K, anticorps p70S6K, anticorps p70[S6 kinase], anticorps p70[S6K], anticorps p70[S6k], anticorps p70[S6kinase], anticorps p70s6K, anticorps s6k, anticorps s6k11, anticorps 2610318I15Rik, anticorps 4732464A07Rik, anticorps 70kDa, anticorps AA959758, anticorps AI256796, anticorps AI314060, anticorps p70/85s6k, anticorps p70s6k, anticorps p70s6k-A, anticorps p70-s6k, anticorps ps6k, anticorps rps6kb1, anticorps rps6kb1-A, anticorps s6K1, anticorps stk14a, anticorps fc51h01, anticorps wu:fc51h01, anticorps zgc:55713, anticorps ribosomal protein S6 kinase B1, anticorps Ribosomal protein S6 kinase, anticorps ribosomal protein S6 kinase, polypeptide 1, anticorps ribosomal protein S6 kinase B1 L homeolog, anticorps ribosomal protein S6 kinase B1 S homeolog, anticorps ribosomal protein S6 kinase b, polypeptide 1b, anticorps RPS6KB1, anticorps S6k, anticorps Rps6kb1, anticorps rps6kb1.L, anticorps rps6kb1.S, anticorps rps6kb1b
Sujet
RPS6KB1 phosphorylates the Ribosomal Protein-S6. Activation of RPS6KB1 requires a complex, ordered series of conformational changes and phosphorylation reactions. While the role of sequential, multi-site phosphorylation has been extensively detailed, characterization of the priming step required to initiate this cascade has remained elusive. Probably this priming process is dependent on calcium. Calcium-dependent regulation of RPS6KB1 does not specifically target Thr-229 and Thr-389, the key regulatory phosphorylation sites, rather, calcium chelation results in a global inhibition of RPS6KB1 phosphorylation. The initial calcium-dependent process is required to release an inhibitory interaction between the C- and N-termini of RPS6KB1, thus allowing phosphorylation of key domains. The priming event involves formation of a calcium-dependent protein complex that releases the interaction between the N- and C-termini. RPS6KB1 is then accessible for activation by the kinases that target the known regulatory phosphorylation sites .
Poids moléculaire
70, 85 kDa
ID gène
6198
NCBI Accession
NP_003152
UniProt
P23443
Pathways
Signalisation PI3K-Akt , Signalisation RTK , AMPK Signaling , Regulation of Cell Size , Skeletal Muscle Fiber Development , Feeding Behaviour , G-protein mediated Events , Smooth Muscle Cell Migration , Interaction of EGFR with phospholipase C-gamma , L'effet Warburg
Vus récemment
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