CTNNA1 anticorps (AA 143-292) (DyLight 488)

N° du produit ABIN7354656

Détail du produit anti-CTNNA1 anticorps (DyLight 488)

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Épitope: AA 143-292

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTNNA1 est conjugé à/à la DyLight 488

Application: Flow Cytometry (FACS)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG Polyclonal Anti-Human CTNNA1 Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogène: E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.

Information d'application

Indications d'application:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: At 2-8°C for one year. Protect from light. Do not freeze.

Références pour anticorps anti-CTNNA1 (DyLight 488) (ABIN7354656)

Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." dans: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).

Lin, Wu, Li, Wu, Zheng: "Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma." dans: World journal of gastroenterology, Vol. 10, Issue 22, pp. 3235-9, (2005) (PubMed).

Détails sur CTNNA1

Antigène: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Autre désignation: CTNNA1 (CTNNA1 Produits)

Synonymes: anticorps CAP102, anticorps 2010010M04Rik, anticorps AA517462, anticorps AI988031, anticorps Catna1, anticorps CG17947, anticorps CT39986, anticorps Dalpha-Cat, anticorps Dalpha-cat, anticorps DalphaC, anticorps Dalphacat, anticorps Dmcatp, anticorps Dmel\\CG17947, anticorps a-Cat, anticorps a-cat, anticorps alpha-CAT, anticorps alpha-cat, anticorps alpha-catenin, anticorps alpha-ctn, anticorps alphaCAT, anticorps alphaCat, anticorps alphacat, anticorps Alpha-Cat, anticorps dgri_GLEANR_3829, anticorps DgriGH19548, anticorps GH19548, anticorps ctnna, anticorps cap102, anticorps catna1, anticorps ctnna1, anticorps catenin alpha 1, anticorps catenin (cadherin associated protein), alpha 1, anticorps alpha Catenin, anticorps catenin alpha-1, anticorps catenin (cadherin-associated protein), alpha 1, anticorps catenin alpha 1 S homeolog, anticorps CTNNA1, anticorps Ctnna1, anticorps alpha-Cat, anticorps Dgri\alpha-Cat, anticorps Tsp_10127, anticorps ctnna1, anticorps ctnna1.S

Sujet:

Synonyms: Catenin alpha-1, Alpha E-catenin, Cadherin-associated protein, Renal carcinoma antigen NY-REN-13, CTNNA1

Tissue Specificity: Expressed ubiquitously in normal tissues.

Background: CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

UniProt: P35221

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location