E2F8 anticorps

N° du produit ABIN5697585

Détail du produit anti-E2F8 anticorps

Antigène: E2F8 (E2F Transcription Factor 8 (E2F8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogène: E2F transcription factor 8

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur E2F8

Antigène: E2F8 (E2F Transcription Factor 8 (E2F8))

Autre désignation: E2F8 (E2F8 Produits)

Synonymes: anticorps MGC130750, anticorps E2F8, anticorps E2F-8, anticorps RGD1308091, anticorps 4432406C08Rik, anticorps AA410048, anticorps E2F transcription factor 8, anticorps E2F transcription factor 8 L homeolog, anticorps E2F8, anticorps e2f8.L, anticorps e2f8, anticorps E2f8

Sujet: Synonyms: Background:Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Poids moléculaire: 82 kDa, 105 kDa

ID gène: 79733

UniProt: A0AVK6