HERC5 anticorps

N° du produit ABIN5699392

Détail du produit anti-HERC5 anticorps

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HERC5 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: hect domain and RLD 5

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur HERC5

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Autre désignation: HERC5 (HERC5 Produits)

Synonymes: anticorps HERC5, anticorps CEB1, anticorps CEBP1, anticorps HECT and RLD domain containing E3 ubiquitin protein ligase 5, anticorps hect domain and RLD 5, anticorps HERC5

Sujet: Synonyms:CEB1, CEBP1 Background:Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence, ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

Poids moléculaire: 117 kDa

ID gène: 51191

UniProt: Q9UII4