PIM2 anticorps

N° du produit ABIN5701191

Détail du produit anti-PIM2 anticorps

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIM2 est non-conjugé

Application: ELISA, Immunoprecipitation (IP)

Immunogène: pim-2 oncogene

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur PIM2

Antigène: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Autre désignation: PIM2 (PIM2 Produits)

Synonymes: anticorps cb1068, anticorps fj47b05, anticorps pim2, anticorps wu:fj47b05, anticorps DXCch3, anticorps Pim-2, anticorps Pim-2 proto-oncogene, serine/threonine kinase, anticorps proviral integration site 2, anticorps pim2, anticorps PIM2, anticorps Pim2

Sujet: Synonyms: Background:Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1(mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade, this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

ID gène: 11040

UniProt: Q9P1W9