RIPK2 anticorps

N° du produit ABIN5701253

Détail du produit anti-RIPK2 anticorps

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Immunogène: receptor-interacting serine-threonine kinase 2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur RIPK2

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Autre désignation: RIPK2 (RIPK2 Produits)

Synonymes: anticorps RIPK2, anticorps 2210420D18Rik, anticorps CARD3, anticorps CARDIAK, anticorps CCK, anticorps D4Bwg0615e, anticorps RICK, anticorps RIP2, anticorps GIG30, anticorps receptor interacting serine/threonine kinase 2, anticorps receptor (TNFRSF)-interacting serine-threonine kinase 2, anticorps receptor-interacting serine-threonine kinase 2, anticorps RIPK2, anticorps Ripk2

Sujet: Synonyms:CARDIAK, RICK, RIP2 Background:Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor(TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

ID gène: 8767

UniProt: O43353

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades