Deltex Homolog 1 anticorps

N° du produit ABIN5701820

Détail du produit anti-Deltex Homolog 1 anticorps

Antigène: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Deltex Homolog 1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogène: deltex homolog 1 (Drosophila)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Date de péremption: 12 months

Détails sur Deltex Homolog 1

Antigène: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Autre désignation: DTX1 (DTX1 Produits)

Synonymes: anticorps hDx-1, anticorps Fxit1, anticorps mKIAA4160, anticorps deltex, anticorps dtx, anticorps xdtx1, anticorps deltex E3 ubiquitin ligase 1, anticorps deltex homolog 1 (Drosophila), anticorps deltex 1, E3 ubiquitin ligase, anticorps deltex 1 L homeolog, anticorps deltex 1 S homeolog, anticorps DTX1, anticorps dtx1, anticorps Dtx1, anticorps dtx1.L, anticorps dtx1.S

Sujet: Synonyms: Background:Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Poids moléculaire: 67-72,58-63 kDa

ID gène: 1840

UniProt: Q86Y01

Pathways: Signalisation Notch