RGMA anticorps
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- Antigène Voir toutes RGMA Anticorps
- RGMA (RGM Domain Family, Member A (RGMA))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RGMA est non-conjugé
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Application
- ELISA, Western Blotting (WB), Immunoprecipitation (IP)
- Immunogène
- RGM domain family, member A
- Isotype
- IgG
- Top Product
- Discover our top product RGMA Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze / thaw cycles.
- Stock
- -20 °C
- Date de péremption
- 12 months
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- Antigène
- RGMA (RGM Domain Family, Member A (RGMA))
- Autre désignation
- RGMA (RGMA Produits)
- Synonymes
- anticorps RGM, anticorps BC059072, anticorps C230063O06, anticorps repulsive guidance molecule family member a, anticorps repulsive guidance molecule family member A, anticorps RGMA, anticorps Rgma
- Sujet
- Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
- ID gène
- 56963
- UniProt
- Q96B86
- Pathways
- Tube Formation
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