RPS6KB1 anticorps (Ser418)

N° du produit ABIN5957336

Détail du produit anti-RPS6KB1 anticorps

Antigène: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Épitope: Ser418

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPS6KB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: 70 kDa ribosomal protein S6 kinase 1,KS6B1,p70 alpha,P70 beta 1,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70 S6 kinase alpha,P70 S6 Kinase,p70 S6 kinase,alpha 1,p70 S6 kinase,alpha 2,p70 S6K,p70 S6K-alpha,p70 S6KA,p70(S6K) alpha,p70(S6K)-alpha,p70-alpha,p70-S6K 1,p70-S6K,P70S6K,P70S6K1,p70S6Kb,PS6K,Ribosomal protein S6 kinase 70  kDa polypeptide 1,Ribosomal protein S6 kinase beta 1,Ribosomal protein S6 kinase beta-1,Ribosomal protein S6 kinase I,RPS6KB1,S6K,S6K-beta-1,S6K1,Serine/threonine kinase 14 alpha,Serine/threonine-protein kinase 14A,STK14A

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human p70 S6 kinase alpha around the non-phosphorylation site of S418.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RPS6KB1

Antigène: RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))

Autre désignation: p70 S6 kinase alpha (RPS6KB1 Produits)

Synonymes: anticorps PS6K, anticorps S6K, anticorps S6K-beta-1, anticorps S6K1, anticorps STK14A, anticorps p70 S6KA, anticorps p70(S6K)-alpha, anticorps p70-S6K, anticorps p70-alpha, anticorps 10539, anticorps 7084, anticorps CG10539, anticorps DS6K, anticorps Dmel\\CG10539, anticorps Dp70S6k, anticorps Dp70[s6k], anticorps Dp70s6k, anticorps S6k, anticorps dS6K, anticorps dS6k, anticorps dp70[S6k], anticorps dp70s6k, anticorps dps6k, anticorps ds6k, anticorps fs(3)07084, anticorps l(3)07084, anticorps p70 S6K, anticorps p70/S6K, anticorps p70S6K, anticorps p70[S6 kinase], anticorps p70[S6K], anticorps p70[S6k], anticorps p70[S6kinase], anticorps p70s6K, anticorps s6k, anticorps s6k11, anticorps 2610318I15Rik, anticorps 4732464A07Rik, anticorps 70kDa, anticorps AA959758, anticorps AI256796, anticorps AI314060, anticorps p70/85s6k, anticorps p70s6k, anticorps p70s6k-A, anticorps p70-s6k, anticorps ps6k, anticorps rps6kb1, anticorps rps6kb1-A, anticorps s6K1, anticorps stk14a, anticorps fc51h01, anticorps wu:fc51h01, anticorps zgc:55713, anticorps ribosomal protein S6 kinase B1, anticorps Ribosomal protein S6 kinase, anticorps ribosomal protein S6 kinase, polypeptide 1, anticorps ribosomal protein S6 kinase B1 L homeolog, anticorps ribosomal protein S6 kinase B1 S homeolog, anticorps ribosomal protein S6 kinase b, polypeptide 1b, anticorps RPS6KB1, anticorps S6k, anticorps Rps6kb1, anticorps rps6kb1.L, anticorps rps6kb1.S, anticorps rps6kb1b

Sujet: P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.

Poids moléculaire: 59kDa

ID gène: 6198

UniProt: P23443

Pathways: Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Skeletal Muscle Fiber Development, Feeding Behaviour, G-protein mediated Events, Smooth Muscle Cell Migration, Interaction of EGFR with phospholipase C-gamma, L'effet Warburg