Clusterin anticorps

N° du produit ABIN5962710

Détail du produit anti-Clusterin anticorps

Antigène: Clusterin (CLU)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: 40,AAG 4,AAG4,Aging associated protein 4,Aging-associated gene 4 protein,AI893575,APO J,Apo-J,APOJ,ApoJalpha,ApoJbeta,Apolipoprotein J,ApolipoproteinJ,CLI,CLU,CLU1,CLU2,CLUS,Clusterin alpha chain,Clusterin,Clusterin beta chain,Complement associated protein SP 40 40,Complement associated protein SP 40,Complement associated protein SP40,Complement cytolysis inhibitor a chain,Complement cytolysis inhibitor,Complement cytolysis inhibitor b chain,Complement lysis inhibitor,Complement-associated protein SP-40,D14Ucla3,Dimeric acid glycoprotein,Glycoprotein 80,Glycoprotein III,GP80,Ku70-binding protein 1,KUB 1,KUB1,MGC24903,NA1/NA2,RATTRPM2B,SGP 2,SGP2,SP 40,SP40,Sugp-2,Sulfated glycoprotein 2,Testosterone repressed prostate message 2,Testosterone-repressed prostate message 2,TRPM 2,TRPM-2,TRPM2,TRPM2B,Trpmb

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human CLUS Polyclonal

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide,0.5 % BSA and 50 % glycerol  pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: CLUS (CLU Produits)

Synonymes: anticorps LOC100136120, anticorps clu, anticorps MGC53055, anticorps zgc:73352, anticorps xclu, anticorps MGC89163, anticorps CLU, anticorps APO-J, anticorps APOJ, anticorps CLI, anticorps CLU1, anticorps CLU2, anticorps KUB1, anticorps NA1/NA2, anticorps SGP-2, anticorps SGP2, anticorps SP-40, anticorps TRPM-2, anticorps TRPM2, anticorps DAG, anticorps RATTRPM2B, anticorps SP40, anticorps TRPM2B, anticorps Trpm2, anticorps Trpmb, anticorps AI893575, anticorps ApoJ, anticorps Cli, anticorps D14Ucla3, anticorps Sgp-2, anticorps Sgp2, anticorps Sugp-2, anticorps GP80, anticorps gpIII, anticorps 40, anticorps clusterin-1, anticorps clusterin L homeolog, anticorps clusterin, anticorps Clusterin, anticorps LOC100136120, anticorps clu.L, anticorps clu, anticorps CLU, anticorps clus, anticorps Clu, anticorps LOC101113728

Sujet: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

ID gène: 1191

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling