Aconitase 1 anticorps
-
- Antigène Voir toutes Aconitase 1 (ACO1) Anticorps
- Aconitase 1 (ACO1)
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Aconitase 1 est non-conjugé
-
Application
- Western Blotting (WB)
- Réactivité croisée
- Souris, Rat
- Attributs du produit
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogène
- A synthetic peptide of human IREB1
- Isotype
- IgG
- Top Product
- Discover our top product ACO1 Anticorps primaire
-
-
- Indications d'application
- WB,1:500 - 1:1000
- Commentaires
-
HIGH QUALITY
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Antigène
- Aconitase 1 (ACO1)
- Autre désignation
- ACO1 (ACO1 Produits)
- Synonymes
- anticorps ACONS, anticorps IREB1, anticorps IREBP, anticorps IREBP1, anticorps IRP1, anticorps Acon1, anticorps Ratireb, anticorps ratireb, anticorps Aco1, anticorps AI256519, anticorps Aco-1, anticorps Irebp, anticorps Irp1, anticorps aconitase 1, anticorps aconitase 1, soluble, anticorps aconitase 1 L homeolog, anticorps ACO1, anticorps Aco1, anticorps aco1.L
- Sujet
- The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants,ACO1,ACONS,HEL60,IREB1,IREBP,IREBP1,IRP1,Epigenetics & Nuclear Signaling,Signal Transduction,Endocrine & Metabolism,Nucleotide metabolism,Cardiovascular,Blood,ACO1
- Poids moléculaire
- 98 kDa
- ID gène
- 48
- UniProt
- P21399
- Pathways
- Transition Metal Ion Homeostasis
-