Integrin beta 4 anticorps (CF®647)
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- Antigène Voir toutes Integrin beta 4 (ITGB4) Anticorps
- Integrin beta 4 (ITGB4)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Integrin beta 4 est conjugé à/à la CF®647
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Reagent (BR)
- Fonction
- Mouse Monoclonal anti-CD104 (UM-A9), CF647 Conjugate
- Attributs du produit
- This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogène
- Human squamous cell carcinoma (UM-SCC1)
- Clone
- UM-A9
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product ITGB4 Anticorps primaire
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- Indications d'application
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Biological blockade partially blocks laminin binding
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Optimal dilution for a specific application should be determined by user
- Commentaires
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A431 cells, squamous cell carcinoma, colon or placenta
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Protect from light
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- Antigène
- Integrin beta 4 (ITGB4)
- Autre désignation
- CD104 (ITGB4 Produits)
- Synonymes
- anticorps AA407042, anticorps C230078O20, anticorps CD104, anticorps integrin subunit beta 4, anticorps integrin beta 4, anticorps ITGB4, anticorps Itgb4
- Sujet
- GP150, Integrin beta-4, ITGB4
- Poids moléculaire
- 205 kDa
- ID gène
- 3691, 632226
- UniProt
- P16144
- Pathways
- Integrin Complex
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