NGFR anticorps
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- Antigène Voir toutes NGFR Anticorps
- NGFR (Nerve Growth Factor Receptor (NGFR))
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Reactivité
- Humain, Lapin, Cat, Furet, Singe, Babouin
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp NGFR est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Fonction
- Mouse Monoclonal anti-NGFR (Nerve-Growth Factor Receptor) (NGFR5), Purified, with BSA
- Attributs du produit
- This antibody recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Purification
- Purified
- Immunogène
- NGFR from A875 melanoma cells
- Clone
- NGFR5
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product NGFR Anticorps primaire
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- Indications d'application
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Does not react with mouse or rat, others not known
- Immunohistology formalin-fixed 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 200 μg/mL
- Buffer
- PBS/0.05 % BSA/0.05 % azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- NGFR (Nerve Growth Factor Receptor (NGFR))
- Autre désignation
- NGFR (Nerve-Growth Factor Receptor) (NGFR Produits)
- Synonymes
- anticorps ngfr, anticorps wu:fb38c02, anticorps wu:fc10h01, anticorps CD271, anticorps Gp80-LNGFR, anticorps TNFRSF16, anticorps p75(NTR), anticorps p75NTR, anticorps LNGFR, anticorps RNNGFRR, anticorps Tnfrsf16, anticorps p75, anticorps NRH1b, anticorps fullback, anticorps nrh1, anticorps p75ntr, anticorps tnfrsf16, anticorps p75NGFR, anticorps nerve growth factor receptor, anticorps neurotrophin receptor associated death domain, anticorps nerve growth factor receptor S homeolog, anticorps nerve growth factor receptor (TNFR superfamily, member 16), anticorps NGFR, anticorps nradd, anticorps Ngfr, anticorps ngfr.S
- Poids moléculaire
- 75 kDa
- ID gène
- 4804
- UniProt
- P08138
- Pathways
- Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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