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IGF1R anticorps (pTyr1280)
IGF1R
Reactivité: Humain, Souris, Rat
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-IGF1R anticorps
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Antigène
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IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Épitope
Tous les épitopes à travers IGF1R Anticorps.
pTyr1280
Reactivité
Toutes les réactivités sur IGF1R Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur IGF1R Anticorps
Lapin
Clonalité
Toutes les clonalités sur IGF1R Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers IGF1R Anticorps
Cet anticorp IGF1R est non-conjugé
Application
Tous les applications à travers IGF1R Anticorps.
Western Blotting (WB)
Specificité
This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.
Réactivité croisée (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity-chromatography using epitope-specific peptide
Immunogène
Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store (in aliquots) at -20 °C.
Détails sur IGF1R
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Antigène
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Autre désignation
CD221 / IGF1R (IGF1R Produits )
Synonymes
anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra
Sujet
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor
ID gène
3480
NCBI Accession
NP_000866
UniProt
P08069
Pathways
Signalisation RTK , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagy
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